Plantar fibromatosis and Dupuytren's disease: an association to remember in patients with diabetes

Diabetic Medicine, Volume 24, Issue 11, Page 1305, November 2007. (Source: Diabetic Medicine)

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A Clinical Analysis of Dupuytren's Disease of the Thumb.

This study examined the pattern of cords of Dupuytren's disease in 260 thumbs in 181 consecutive patients with evidence of disease relating to the thumb attending an out-patient clinic over a period of 36 months. Discrepancies in the literature are discussed in the light of the findings of this more detailed analysis and a simple but practical pictorial system for recording disease severity and detailing progression over time is presented. PMID: 18562356 [PubMed - as supplied by publisher] (Source: The Journal of Hand Surgery)

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Auxilium Pharmaceuticals, Inc.: Auxilium Pharmaceuticals, Inc. Announces First Patients Dosed in XIAFLEX(TM) U.S. Pivotal Phase III Study

MALVERN, PA (MARKET WIRE) Auxilium Pharmaceuticals, Inc. (NASDAQ: AUXL) today announced that the first patients have been dosed in the Company's second U.S. phase III pivotal trial and the Australian phase III study for XIAFLEX(TM) for the treatment of Dupuytren's contracture, a disabling and recurring condition in which the joints in the hand contract, impairing patients' ability to straighten and move their fingers. (Source: Market Wire - Pharmaceuticals and Biotech)
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FDA Advisory Committee Recommends Approval of Xiaflex for Dupuytren's Contracture

On September 16, the FDA's Arthritis Advisory Committee voted unanimously 12 to 0 to recommend approval of collagenase clostridium histolyticum for Dupuytren's contracture. Medscape Medical News (Source: Medscape Today Headlines)
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Auxilium Pharmaceuticals Announces Top-Line Results From A Pivotal Efficacy Study Of AA4500 In Dupuytren's Disease

AuxiliumPharmaceuticals, Inc. (Nasdaq: AUXL) today reported top-line results from apivotal efficacy study of AA4500, its injectable enzyme product, inpatients with Dupuytren's Disease. The Company also announced its decisionto pursue additional sources of commercial supply for AA4500 and revisedfinancial guidance with respect to Research and Development costs andfull-year loss for 2006. [click link for full article] (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

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Hands across the water: clinical observations of hand therapy practices in Great Britain and Norway.

Authors: Schwartz DA The Evelyn Mackin Traveling Hand Therapist Award is a new award established in 2004 by the American Hand Therapy Foundation. This award was named in honor of Evelyn Mackin, a distinguished leader in hand therapy rehabilitation. Ms. Mackin enthusiastically endorses worldwide networking among hand therapists. She strongly believes in the value of sharing knowledge and technical skills. This award enables members of the ASHT to travel, learn new concepts or skills, and share them with the American hand therapy community. Visits to clinics in Great Britain and Norway revealed similarities and differences between European and American hand therapy practice. Clinical observations explore tendon transfer rehabilitation, cold sensitivity, sensory desensitization and re-edu...

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Auxilium Pharmaceuticals, Inc.: Auxilium Pharmaceuticals, Inc. Completes Enrollment in Two Phase III Clinical Trials of XIAFLEX(TM) for Dupuytren's Contracture

MALVERN, PA (MARKET WIRE) Auxilium Pharmaceuticals, Inc. (NASDAQ: AUXL) today announced that it has completed patient enrollment in the Company's second U.S. phase III pivotal trial (CORD I) and its Australian phase III study (CORD II) of XIAFLEX™ (clostridial collagenase for injection) for the treatment of Dupuytren's contracture. In accordance with the study design, all enrolled patients have received their first injection of either XIAFLEX or placebo. Due to the high level of interest from patients and physicians, the Company was able to exceed its enrollment targets in both studies, with greater than 300 (Source: Market Wire - Pharmaceuticals and Biotech)

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[Dupuytren's disease]

Authors: Tr�ves R Dupuytren's disease is a contracture of the hand derived from the retractile fibrosis of the palmar aponeurosis, that leads to a progressive deformity in flexion of fingers. It has been named from the French surgeon Guillaume Dupuytren (1777-1835), that described it in 1831. In this note it is sketched a short biography of Dupuytren and the main clinical features of the disease are described, underlining some particular aspects of therapy. PMID: 17013443 [PubMed - in process] (Source: Reumatismo)

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Needle aponeurotomy for Dupuytren's contracture.

CONCLUSION. For Chinese patients with Dupuytren's contracture, needle aponeurotomy is safe and effective. Long-term correction is better maintained in metacarpophalangeal than proximal interphalangeal joints (70 vs 41%). PMID: 18453667 [PubMed - in process] (Source: Journal of Orthopaedic Surgery)
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Blueberry Wheat Beer Making Kit - Pick From 6 Flavors

$32.00 End Date: Saturday Oct-24-2009 14:00:39 PDT Buy It Now for only: US $32.00 Buy it now

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Phenobarbital: Dupuytren's contracture: 3 case reports.

Page: 36 (Source: Reactions Weekly)

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Enzyme injections may treat Dupuytren's contracture

Scientists believe that injections of an enzyme called collagenase may help to treat a condition called Dupuytren's contracture, which causes the fingers to bend and fail to extend properly. (Source: Arthritis Research Campaign)

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Discovery Of New Treatment For Hand Disorder Affecting Millions Shown Promising

Researchers in the Department of Orthopaedics at Stony Brook University Medical Center have developed an injectable form of the enzyme, collagenase, that significantly improves outcomes of Dupuytren's contracture (or disease), a debilitating disorder caused by progressive accumulation of collagen that deforms fingers and limits motion. (Source: Health News from Medical News Today)
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Does a 'firebreak' full-thickness skin graft prevent recurrence after surgery for Dupuytren's contracture?: A PROSPECTIVE, RANDOMISED TRIAL.

Authors: Ullah AS, Dias JJ, Bhowal B We randomised 79 patients (84 hands, 90 fingers) with Dupuytren's contracture of the proximal interphalangeal joint to have either a 'firebreak' skin graft (39 patients, 41 hands, 44 fingers) or a fasciectomy (40 patients, 43 hands, 46 fingers) if, after full correction, the skin over the proximal phalanx could be easily closed by a Z-plasty. Patients were reviewed after three, six, 12, 24 and 36 months to note any complications, the range of movement and recurrence. Both groups were similar in regard to age, gender and factors considered to influence the outcome such as bilateral disease, family history, the presence of diabetes, smoking and alcohol intake. The degree of contracture of the metacarpophalangeal and interphalangeal joints of the opera...
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Links Between Peyronie���s Disease And Dupuytren���s Disease

According to a report published in 1995 by the National Institutes of Health, Peyronie�"s disease occurs in about 1% of men. About 30 percent of men with Peyronie�"s disease develop fibrosis (ha...
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