FDA Approves Xiaflex For Debilitating Hand Condition

The U.S. Food and Drug Administration recently approved Xiaflex (collagenase clostridium histolyticum) as the first drug to treat a progressive hand disease known as Dupuytren's contracture, which can affect a person's ability to straighten and properly use their fingers. (Source: Pharmaceutical Online News)
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Plantar fibromatosis and Dupuytren's disease: an association to remember in patients with diabetes

Diabetic Medicine, Volume 24, Issue 11, Page 1305, November 2007. (Source: Diabetic Medicine)

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A Clinical Analysis of Dupuytren's Disease of the Thumb.

This study examined the pattern of cords of Dupuytren's disease in 260 thumbs in 181 consecutive patients with evidence of disease relating to the thumb attending an out-patient clinic over a period of 36 months. Discrepancies in the literature are discussed in the light of the findings of this more detailed analysis and a simple but practical pictorial system for recording disease severity and detailing progression over time is presented. PMID: 18562356 [PubMed - as supplied by publisher] (Source: The Journal of Hand Surgery)

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Auxilium Pharmaceuticals, Inc.: Auxilium Pharmaceuticals, Inc. Announces First Patients Dosed in XIAFLEX(TM) U.S. Pivotal Phase III Study

MALVERN, PA (MARKET WIRE) Auxilium Pharmaceuticals, Inc. (NASDAQ: AUXL) today announced that the first patients have been dosed in the Company's second U.S. phase III pivotal trial and the Australian phase III study for XIAFLEX(TM) for the treatment of Dupuytren's contracture, a disabling and recurring condition in which the joints in the hand contract, impairing patients' ability to straighten and move their fingers. (Source: Market Wire - Pharmaceuticals and Biotech)
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FDA Advisory Committee Recommends Approval of Xiaflex for Dupuytren's Contracture

On September 16, the FDA's Arthritis Advisory Committee voted unanimously 12 to 0 to recommend approval of collagenase clostridium histolyticum for Dupuytren's contracture. Medscape Medical News (Source: Medscape Today Headlines)
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